Hypertriglyceridemia Induced By L-Asparaginase and Prednisolone in Pediatric Hemato-Oncology: A Case Report

Immunotherapy in pediatric hemato - oncology

Familial hypertriglyceridemia-induced acute necrotizing pancreatitis: A case report

Acutepancreatitis can infrequently be a life-threatening complication of hypertriglyceridemia. Rarely, hypertriglyceridemia can originate from an inborn genetic error in lipoproteins metabolism. This condition can be manifested by very high serum triglyceride levels (>1000 mg/dl) and a more severe and lethal form of pancreatitis. Here, we present a case of acute pancreatic which was found out t...

PEG-asparaginase induced severe hypertriglyceridemia.

Asparaginase (ASP) is an effective chemotherapy agent extensively used in children with acute lymphocytic leukemia (ALL). There has been a recent interest in using ASP in adults with ALL, particularly the less toxic pegylated (PEG) formulation. Hypertriglyceridemia (HTG) is a rare complication of PEG-ASP therapy. We report two cases of obese patients who developed severe HTG after receiving PEG...

Characterization of hypertriglyceridemia induced by L-asparaginase therapy for acute lymphoblastic leukemia and malignant lymphoma.

Plasma lipids and apolipoproteins were determined in 19 children with acute lymphoblastic leukemia (ALL) or malignant lymphoma (ML) who were treated by L-asparaginase with prednisolone and vincristine. Extreme hypertriglyceridemia, i.e., over 10,000 mg/l of the maximum serum triglyceride concentration, was induced in 8 patients; these concentrations were not over 10,000 mg/l in the remaining 11...

Pediatric Oncology Drug Development: A Case Report and Pathways Forward

In this case report, we briefly review the treatment of a patient with metastatic, refractory Ewing's sarcoma who was treated on a Phase I clinical trial before she died from progressive disease. The case illustrates the need for early phase clinical trials programs in pediatric oncology, and the way in which investigators approach such programs.